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918504-65-1 CAS NO.918504-65-1
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,
- Product Details
Keywords
- 918504-65-1
- N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
- C23H18ClF2N3O3S
Quick Details
- ProName: 918504-65-1
- CasNo: 918504-65-1
- Molecular Formula: C23H18ClF2N3O3S
- Appearance: White or off-white Solid
- Application: intermediate
- DeliveryTime: 20day
- PackAge: According to the demand of customer
- Port: shanghai
- ProductionCapacity: 20 Metric Ton/Day
- Purity: 99.0%
- Storage: Sealed, dry, microtherm , avoid light ...
- Transportation: According to the demand of customer
- LimitNum: 1 Kilogram
- Grade: Industrial Grade,Pharma Grade,Electron...
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Details
| N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Basic information |
| Product Name: | N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide |
| Synonyms: | N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide;PLX4032 (VeMurafenib);R7204;N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaM;PLX4032, R7204, RG7204, RO5185426;VeMurafenib (PLX4032, RG7204);N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide Vemurafenib PLX 4032;Zelboraf (vemurafenib) |
| CAS: | 918504-65-1 |
| MF: | C23H18ClF2N3O3S |
| MW: | 489.9221264 |
| EINECS: | |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;Sulfur & Selenium Compounds;API;Inhibitor;RG7204;Antineoplastic |
| Mol File: | 918504-65-1.mol |
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| N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Chemical Properties |
| density | 1.46 |
| Safety Information |
| N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Usage | Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. |
| Usage | Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM |
| N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Preparation Products And Raw materials |