China (Mainland)
Premiumsupplier 
Ebastine CAS NO.90729-43-4
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,
- Product Details
Keywords
- 90729-43-4
- Ebastine
- C32H39NO2
Quick Details
- ProName: Ebastine
- CasNo: 90729-43-4
- Molecular Formula: C32H39NO2
- Appearance: White or off-white Solid
- Application: Organic synthesis
- DeliveryTime: 20day
- PackAge: According to the demand of customer
- Port: shanghai
- ProductionCapacity: 20 Metric Ton/Month
- Purity: 98%
- Storage: Sealed, dry, microtherm , avoid light ...
- Transportation: by air or by sea
- LimitNum: 1 Kilogram
- Grade: Industrial Grade,Pharma Grade,Electron...
Superiority
he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice
Details
v Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long-term professional development team engaging in the fine chemicals, Henan Allgreen Chemical Co.,Ltd is mainly engaged in development and customized of organic electronic chemical materials, metal catalysts, phosphorus ligands, medical intermediate , chemical reagent and other fine chemical products.We have multifunctional production conditions and could offer high quality products from grams to kilograms and tons. In addition, we absorb new technology actively from colleges and also have established good relations of cooperation with Huazhong University of Science and Technology ,Henan Institute of Engineering and some other well-known domestic enterprises. Our products have been exported to Japan, South Korea, Europe, America and other countries and regions, well received by customers.
With sound management system, we've been authorized the Import&Export qualification by the government and also has passed the “ISO 9001-2008 Quality Management System” certification. We always stand on the quality of product as our life, develop in the direction of customers requirement and aim at creating greater value for customers.Innovation and honesty, we will make common development with the masses of customers at home and abroad hand in hand by our best service.
| Ebastine Basic information |
| Product Name: | Ebastine |
| Synonyms: | 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one;EBASTEL;EBASTIN;EBASTINE;EVASTEL;KESTINE;1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-1-buta;1-butanone,1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidiny |
| CAS: | 90729-43-4 |
| MF: | C32H39NO2 |
| MW: | 469.66 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors |
| Mol File: | 90729-43-4.mol |
|
|
|
| Ebastine Chemical Properties |
| Melting point | 80-82°C |
| storage temp. | Room temp |
| CAS DataBase Reference | 90729-43-4(CAS DataBase Reference) |
| Safety Information |
| RTECS | EL8140000 |
| Ebastine Usage And Synthesis |
| Antihistamines |
Antihistamines are class of drugs which are able to compete histamine receptors on cells with histamine , which makes histamine can not be combined with histamine receptors, resulting in an anti-histamine effect , according to the different types of histamine receptors, antihistamines can be divided into H1 receptor blockers and H2 receptor blockers, H1 receptor antagonists are antihistamines that are generally referred to in the past, which can antagonize the relaxation of vascular and smooth muscle contraction action of histamine and help to alleviate or eliminate allergy symptoms caused by endogenous release of histamine.It is mainly used for prevention and treatment of skin and mucous allergic diseases, motion sickness and vomiting. Ebastine and cetirizine, loratadine, cetirizine L, mizolastine are several currently used anti-H1 receptor antihistamines which are non-sedating ,they are anti-allergic drugs, which is characterized by the central nervous non-sedating or little sedating ,their anti-histamine effect is stronger, which can significantly inhibit flush and wind group caused by the histamine , it does not affect the mast cells to release histamine. This product starts effect 1 to 4 hours after oral administration , time to peak plasma concentration is 3 to 6 hours, it can go through the blood-brain barrier, it is converted to an active form carebastine in vivo. Healthy adult volunteers after once po ebastine, Tmax is about 3 ~ 6 h, 3 ~ 5 times / d administration can make plasma concentrations reach steady state. After single serving 10 mg, Cmax is approximately 0.1mg / L. Administration with food may increase its bioavailability. PPB is about 98%. Vd is about 90 ~ 140 L. Terminal T1 / 2 is 13 ~ 16h, it is mainly excreted in the urine. The main clinical uses are for the treatment of various allergic diseases such as chronic idiopathic urticaria, seasonal, perennial allergic rhinitis, skin pruritus. Adult treatment of chronic urticaria, or allergic rhinitis, po, 10 mg, qd; the amount of children is 5 mg, qd. Large doses of ebastine 20 mg, qd are only for more severe allergic diseases in adults, and Administration in the morning will achieve better results. The most common adverse events are somnolence, headache, dry mouth, most patients have mild to moderate reactions,which does not affect the uses. Other rare adverse reactions are fatigue, nausea, vomiting, loss of appetite, hyperactivity, diarrhea, constipation and upset. Up to 1 year or more use of drugs observation, the most common adverse reactions are headache and gastrointestinal disorders. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | Ebastine Fumarate: Crystallize from ethanol, mp 197-198 ℃. Acute toxicity LD50 rodent (mg / kg): 500 intraperitoneal injection;> 4,000 oral. |
| Uses | Its antihistamine activity is competitive at low concentrations,while it is non-competitive at high concentrations. It is used for allergic diseases, including children allergic rhinitis , adults year-round rhinitis, seasonal rhinitis, hay fever and chronic urticaria. |
| Chemical Properties | White to Off-White Powder |
| Usage | A nonsedating type histamine H1-receptor antagonist. Antihistaminic |
| Ebastine Preparation Products And Raw materials |
| Raw materials | 4-Hydroxypiperidine -->Bromodiphenylmethane |