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Tizanidine Hydrochloride CAS NO.64461-82-1
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,
- Product Details
Keywords
- 64461-82-1
- Tizanidine Hydrochloride
- C9H9Cl2N5S
Quick Details
- ProName: Tizanidine Hydrochloride
- CasNo: 64461-82-1
- Molecular Formula: C9H9Cl2N5S
- Appearance: White or off-white Solid
- Application: Clinically, it is used to treat the di...
- DeliveryTime: 20 days
- PackAge: According to the demand of customer
- Port: shanghai
- ProductionCapacity: 100 Kilogram/Week
- Purity: 98%
- Storage: Desiccate at RT
- Transportation: by air or by sea
- LimitNum: 1 Kilogram
- Grade: Industrial Grade,Pharma Grade,Electron...
Superiority
Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long-term professional development team engaging in the fine chemicals, Henan Allgreen Chemical Co.,Ltd is mainly engaged in development and customized of organic electronic chemical materials, metal catalysts, phosphorus ligands, medical intermediate , chemical reagent and other fine chemical products. We have multifunctional production conditions and could offer high quality products from grams to kilograms and tons. In addition, we absorb new technology actively from colleges and also have established good relations of cooperation with Huazhong University of Science and Technology, Zhengzhou University, Henan Institute of Engineering. Henan Provincial Institute of chemistryand some other well-known domestic enterprises. Our products have been exported to Japan, South Korea, Europe, America and other countries and regions, well received by customers.
With sound management system, we've been authorized the Import&Export qualification by the government and also has passed the “ISO 9001-2008 Quality Management System” certification. We always stand on the quality of product as our life, develop in the direction of customers requirement and aim at creating greater value for customers.Innovation and honesty, we will make common development with the masses of customers at home and abroad hand in hand by our best service.
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Details
| Tizanidine hydrochloride Basic information |
| Product Name: | Tizanidine hydrochloride |
| Synonyms: | 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2;1,3-benzothiadiazol-4-amine,5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-mono;5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazolehydrochloride;SIRDALUD;TERNELIN;TIZANIDINE HCL;TIZANIDINE HYDROCHLORIDE;ZANAFLEX |
| CAS: | 64461-82-1 |
| MF: | C9H9Cl2N5S |
| MW: | 290.17 |
| EINECS: | |
| Product Categories: | Zanaflex, Sirdalud;Bases & Related Reagents;Heterocycles;Nucleotides;Sulfur & Selenium Compounds;Muscle relaxant (skeletal);Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor |
| Mol File: | 64461-82-1.mol |
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| Tizanidine hydrochloride Chemical Properties |
| Melting point | 280 °C |
| Fp | 9℃ |
| storage temp. | Desiccate at RT |
| solubility | H2O: ~29 mg/mL |
| form | solid |
| color | white |
| Merck | 14,9485 |
| CAS DataBase Reference | 64461-82-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36-37/39 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | DK9910000 |
| HS Code | 2934990002 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Tizanidine hydrochloride Usage And Synthesis |
| Description |
As an adrenergic agonist with muscle relaxant activity, tizanidine hydrochloride belongs to the hydrochloride salt form of tizanidine, which is commonly used in the treatment of spasticity, a condition where muscles in human body spasm, cramp, or become tight induced by a variety of medical problems such as multiple sclerosis, spinal cord injury, Lou Gehrig's disease, spastic diplegia, back pain or certain other injuries to the spine or central nervous system. Besides, as a sleep aid and an anticonvulsant, tizanidine hydrochloride has off-label usage for migraine headaches and is effective for some symptoms of fibromyalgia. As a short-acting muscle relaxer, the antinociceptive effect of tizanidine hydrochloride functions by blocking excess nerve impulses (pain sensations) of the nerve cells that are sent to the brain and control muscle movement, ultimately resulting in muscle relaxation and spasticity alleviation. |
| References |
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| Chemical Properties | Off-White to pale Yellow Solid |
| Originator | Nimzox,Rapross Pharmaceuticals Pvt. Ltd.,India |
| Uses | An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). |
| Uses | Tizanidine (Zanaflex) is a drug that is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia, |
| Uses | Anticoagulant |
| Manufacturing Process | 14 ml of benzoyl chloride are added to a solution of 11.5 g of ammonium thiocyanate in 150 ml of acetone in an ice bath and the mixture is then stirred for 10 min. This solution is heated to the boil at reflux together with 19 g of 4-amino-5-chloro-2,1,3-benzothiadiazole. The solution is cooled to room temperature and diluted with a 4-fold quantity of water. The precipitate is filtered off and rapidly brought to a boil together with 150 ml of a 2 N aqueous sodium hydroxide solution and kept at the boil for 5 min. The solution is cooled to room temperature, is acidified weakly with glacial acetic acid, the precipitate is filtered off, washed with ether and recrystallized from methanol. The N-(5-chloro-2,1,3-benzothiadiazol-4-yl)thiourea, obtained and this is boiled for 1 h together with 9 g of methyl iodide in 150 ml of methanol. After concentrating by evaporation, crude S-methyl-N-(5-chloro-2,1,3- benzothiadiazol-4-yl)isothiuronium iodide is obtained. 9.8 g of S-methyl-N-(5- chloro-2,1,3-benzothiadiazol-4-yl)isothiuronium iodide are heated to the boil at reflux for 1 h together with 50 ml of methanol and 1.8 ml of ethylene diamine. The solvent is then removed by evaporation and the moist residue is boiled at reflux for 1 h together with 20 ml of n-amyl alcohol. The mixture is subsequently shaken with 50 ml of chloroform and 150 ml of water until all the material is dissolved. 40 ml of a 2 N aqueous sodium hydroxide solution are added to the aqueous phase and extraction is effected with 200 ml of chloroform. The organic phase is dried and concentrated by evaporation. After recrystallizing the residue from methanol with the addition of some active charcoal, 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole, having a melting point of 221-223°C, is obtained. The 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole hydrochloride may be obtained by the teaction of 4-(2-imidazolin-2-yl-amino)-5-chloro- 2,1,3-benzothiadiazole with hydrochloric acid. |
| Brand name | Tizanidine is INN and BAN. |
| Therapeutic Function | Muscle relaxant, Spasmolytic |
| Biological Activity | α 2 -adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC 50 = 48 nM). Also binds to imidazoline receptor. |