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Gefitinib CAS NO.184475-35-2
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,
- Product Details
Keywords
- 184475-35-2
- Gefitinib
- C22H24ClFN4O3
Quick Details
- ProName: Gefitinib
- CasNo: 184475-35-2
- Molecular Formula: C22H24ClFN4O3
- Appearance: White or off-white Solid
- Application: Organic synthesis
- DeliveryTime: 20day
- PackAge: According to the demand of customer
- Port: shanghai
- ProductionCapacity: 20 Metric Ton/Month
- Purity: 98%
- Storage: Sealed, dry, microtherm , avoid light ...
- Transportation: by air or by sea
- LimitNum: 1 Kilogram
- Grade: Industrial Grade,Pharma Grade,Electron...
Superiority
high quality
Details
| Gefitinib Basic information |
| Product Name: | Gefitinib |
| Synonyms: | IRESSA;GEFITINIB;AKOS 91371;n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine;ZD 1839;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-;Gefitinib(TINIBS) |
| CAS: | 184475-35-2 |
| MF: | C22H24ClFN4O3 |
| MW: | 446.9 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;Gefitinib;Molecular Targeted Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;APIs;IRESSA;Anti-cancer&immunity;API |
| Mol File: | 184475-35-2.mol |
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| Gefitinib Chemical Properties |
| mp | 119-1200C |
| storage temp. | Store at RT |
| CAS DataBase Reference | 184475-35-2(CAS DataBase Reference) |
| Safety Information |
| Gefitinib Usage And Synthesis |
| Chemical Properties | Light-Yellow Crystalline Powder |
| Usage | Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. |
| Usage | Gefitinib is an antineoplastic. |
| Biological Activity | Orally active, selective inhibitor of EGFR tyrosine kinase (IC 50 = 23-79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts. |
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Gefitinib Preparation Products And Raw materials |