China (Mainland)
Premiumsupplier 
- Product Details
Keywords
- 104987-11-3
- Tacrolimus
- C44H69NO12
Quick Details
- ProName: Tacrolimus
- CasNo: 104987-11-3
- Molecular Formula: C44H69NO12
- Appearance: white powder
- Application: diagnostic reagent
- DeliveryTime: 20day
- PackAge: meet the demand of customer
- Port: shanghai
- ProductionCapacity: 20 Metric Ton/Month
- Purity: 98%min
- Storage: cold storage
- Transportation: by sea or by air
- LimitNum: 1 Kilogram
Superiority
T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service
Details
Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long-term professional development team engaging in the fine chemicals, Henan Allgreen Chemical Co.,Ltd is mainly engaged in development and customized of organic electronic chemical materials, metal catalysts, phosphorus ligands, medical intermediate , chemical reagent and other fine chemical products.We have multifunctional production conditions and could offer high quality products from grams to kilograms and tons. In addition, we absorb new technology actively from colleges and also have established good relations of cooperation with Huazhong University of Science and Technology ,Henan Institute of Engineering and some other well-known domestic enterprises. Our products have been exported to Japan, South Korea, Europe, America and other countries and regions, well received by customers.
With sound management system, we've been authorized the Import&Export qualification by the government and also has passed the “ISO 9001-2008 Quality Management System” certification. We always stand on the quality of product as our life, develop in the direction of customers requirement and aim at creating greater value for customers.Innovation and honesty, we will make common development with the masses of customers at home and abroad hand in hand by our best service.
| Tacrolimus Basic information |
| Product Name: | Tacrolimus |
| Synonyms: | (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide |
| CAS: | 104987-11-3 |
| MF: | C44H69NO12 |
| MW: | 804.02 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic |
| Mol File: | 104987-11-3.mol |
|
|
|
| Tacrolimus Chemical Properties |
| mp | 113-115°C |
| storage temp. | −20°C |
| solubility | DMSO: >3 mg/mL |
| form | solid |
| color | white |
| CAS DataBase Reference | 104987-11-3(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T,Xi,Xn,F |
| Risk Statements | 25-36/37/38-36-20/21/22-11 |
| Safety Statements | 45-36-26-36/37-16 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | KD4201200 |
| Tacrolimus Usage And Synthesis |
| Chemical Properties | White Crystalline Solid |
| Usage | An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. |
| Usage | FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system |
| Usage | Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα. |
| Usage | treatment of Cushing's syndrome |
| Usage | For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart, |
| Tacrolimus Preparation Products And Raw materials |
| Raw materials | Ethyl acetate-->Celite -->Starch-->Yeast extract-->Active Calcium |